The word masterfully is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Play In The Letters masterfully
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Seven Letter Word Alert: (47 words)
alertly, allures, alumels, amulets, armfuls, armlets, armsful, earfuls, estrual, estuary, fallers, falsely, falters, femural, flamers, flayers, fluster, fluters, fullers, fullest, laurels, mallets, malleus, mastery, matures, maulers, mullers, mullets, myrtles, refusal, refutal, restful, retally, saluter, serumal, smaller, smartly, stellar, streamy, sulfate, sutlery, tearful, tramell, tramels, tramful, trayful, yearful